Bruce Beutler Selected Research

Ethylnitrosourea (N-Ethyl-N-nitrosourea)

1/2022	Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice.
1/2021	Saturation mutagenesis defines novel mouse models of severe spine deformity.
1/2020	Essential requirement for nicastrin in marginal zone and B-1 B cell development.
1/2019	Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice.
1/2017	Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5.
1/2017	Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival.
10/2016	Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.
1/2012	Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses.
12/2011	Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in mice.
11/2010	MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands.

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Bruce Beutler Research Topics

Disease

29	Infections 09/2014 - 10/2001
13	Virus Diseases (Viral Diseases) 10/2016 - 01/2003
8	Colitis 01/2019 - 03/2009
7	Inflammation (Inflammations) 01/2021 - 06/2007
6	Neoplasms (Cancer) 01/2022 - 07/2015
5	Obesity 01/2022 - 12/2006
5	Autoimmune Diseases (Autoimmune Disease) 11/2021 - 05/2007
5	Sepsis (Septicemia) 10/2007 - 10/2001
4	Lymphopenia (Lymphocytopenia) 01/2021 - 05/2007
4	Melanoma (Melanoma, Malignant) 01/2019 - 05/2006
3	Insulin Resistance 01/2020 - 10/2016
3	Vesicular Stomatitis 07/2007 - 06/2005
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2022 - 11/2021
2	Non-alcoholic Fatty Liver Disease 01/2022 - 01/2019
2	Body Weight (Weight, Body) 01/2022 - 01/2010
2	Lipodystrophy 01/2020 - 10/2016
2	Hyperglycemia 01/2020 - 01/2018
2	Hypopigmentation (Hypomelanosis) 01/2020 - 08/2012
2	Lymphadenopathy 12/2018 - 02/2013
2	Splenomegaly 12/2018 - 02/2013
2	Hypersensitivity (Allergy) 01/2018 - 01/2008
2	Alopecia (Baldness) 01/2017 - 12/2005
2	Cardiomyopathies (Cardiomyopathy) 01/2016 - 12/2011
2	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 01/2016 - 03/2014
2	Waldenstrom Macroglobulinemia (Macroglobulinemia) 01/2016 - 03/2014
2	Nephritis 11/2009 - 04/2009
2	Iron Deficiencies 11/2009 - 05/2008
2	Glomerulonephritis 11/2009 - 04/2009
2	Atherosclerosis 10/2009 - 12/2002
2	Cataract (Cataracts) 05/2006 - 07/2005
2	Legionnaires' Disease (Legionnaire's Disease) 02/2005 - 11/2003
1	Congenital Abnormalities (Deformity) 01/2021
1	Retinal Diseases 01/2020
1	Alzheimer Disease (Alzheimer's Disease) 01/2020
1	Hyperinsulinism (Hyperinsulinemia) 01/2020
1	Hypergammaglobulinemia (Hyperimmunoglobulinemia) 01/2020
1	Hidradenitis Suppurativa 01/2020
1	Peritonitis 12/2019
1	Immune System Diseases (Immune Disorders) 10/2019
1	Hyperphagia (Overeating) 12/2018
1	Type 2 Diabetes Mellitus (MODY) 01/2018
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2017

Drug/Important Bio-Agent (IBA)

18	Ethylnitrosourea (N-Ethyl-N-nitrosourea)IBA 01/2022 - 09/2004
18	Toll-Like Receptors (Toll-Like Receptor)IBA 12/2018 - 10/2001
11	Proteins (Proteins, Gene)FDA Link 10/2019 - 09/2004
7	CytokinesIBA 11/2018 - 05/2007
7	LigandsIBA 10/2016 - 11/2003
6	LipidsIBA 01/2022 - 08/2005
6	Dextrans (Dextran)FDA Link 01/2019 - 03/2009
6	Antiviral Agents (Antivirals)IBA 10/2015 - 06/2007
5	Insulin (Novolin)FDA Link 11/2021 - 01/2010
5	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2019 - 03/2009
5	AntigensIBA 11/2018 - 03/2005
4	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 12/2007
4	Interferon Type IIBA 11/2009 - 01/2003
4	LipopolysaccharidesIBA 01/2008 - 01/2006
3	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 01/2018
3	Messenger RNA (mRNA)IBA 10/2019 - 11/2009
3	IronIBA 12/2011 - 05/2008
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2010 - 02/2003
3	Toll-Like Receptor 4IBA 02/2005 - 12/2002
2	Retinaldehyde (Retinal)IBA 01/2020 - 07/2005
2	Nonsense Codon (Nonsense Mutation)IBA 01/2019 - 09/2008
2	diprovocimIBA 01/2019 - 11/2018
2	CholesterolIBA 01/2018 - 01/2017
2	Mechanistic Target of Rapamycin Complex 1IBA 01/2018 - 05/2014
2	Immunoglobulin M (IgM)IBA 12/2014 - 03/2014
2	Adenosine Triphosphate (ATP)IBA 07/2011 - 12/2007
2	KATP ChannelsIBA 07/2011 - 12/2007
2	Pharmaceutical PreparationsIBA 07/2011 - 03/2011
2	Interleukin-12 (IL 12)IBA 07/2011 - 08/2010
2	site 1 membrane-bound transcription factor peptidaseIBA 03/2011 - 03/2009
2	Antigen-Antibody Complex (Immune Complex)IBA 03/2010 - 04/2009
2	HepcidinsIBA 11/2009 - 05/2008
2	DiglyceridesIBA 10/2009 - 09/2006
2	Glycoproteins (Glycoprotein)IBA 10/2009 - 06/2007
2	GlycolipidsIBA 09/2006 - 03/2005
2	EndotoxinsIBA 03/2006 - 05/2003
2	Toll-Like Receptor 2IBA 08/2005 - 06/2005
1	GTP Phosphohydrolases (GTPases)IBA 01/2022
1	Dual-Specificity PhosphatasesIBA 11/2021
1	Sulfoglycosphingolipids (Sulfatides)IBA 01/2021
1	Antigen Receptors (Antigen Receptor)IBA 01/2021
1	AntibodiesIBA 01/2020
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2020
1	Immunoglobulin G (IgG)IBA 01/2020
1	CarcinogensIBA 01/2020
1	Immunoglobulin E (IgE)IBA 01/2020
1	Immunoglobulin A (IgA)IBA 01/2020
1	InflammasomesIBA 12/2019
1	fibroblast growth factor 21IBA 01/2019
1	aluminum sulfate (alum)IBA 11/2018
1	OvalbuminIBA 11/2018
1	Neoplasm Antigens (Tumor Antigens)IBA 11/2018
1	Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)IBA 01/2018
1	Myosins (Myosin)IBA 01/2018
1	CreatineIBA 01/2017
1	Triglycerides (Triacylglycerol)IBA 01/2017

Therapy/Procedure

2	Therapeutics 01/2022 - 12/2011
1	Immunotherapy 11/2018